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Bárbara Mori is of Uruguayan, Native American, Mexican and Japanese heritage. She is an actress and model. Her parents Yuyi Mori and Rosario Ochoa divorced when she was three years of age. Mori spent her early childhood between Mexico and Uruguay and finally settled in Mexico City at the age of twelve with her mom. She has two siblings, actress Kenya Mori and brother Kintaró Mori.

Mori was diagnosed with early stage cancer and is now a proud survivor. She talks about her journey in UniGlobe Entertainment's docu-drama titled 1 a Minute The documentary is being made by actress Namrata Singh Gujral and will also feature cancer survivors Olivia Newton-John, Diahann Carroll, Melissa Etheridge, Namrata Singh Gujral, Mumtaz and Jaclyn Smith as well as William Baldwin, Daniel Baldwin and Priya Dutt, whose lives have been touched by cancer. The feature is narrated by Kelly McGillis. The film will also star Lisa Ray, Deepak Chopra and Morgan Brittany.

She has a son with actor Sergio Mayer but never married him. She currently resides in Montevideo, Uruguay.